Disodium Hydrogen Citrate Syrup – Overview

Learn From Doctor Team
Learn From Doctor Team is made up of well-qualified doctors of different fields with brilliant academic results and professional careers. The article is written and reviewed by doctors of this specialty.

What is Disodium Hydrogen Citrate Syrup?

Disodium Hydrogen Citrate Syrup is an alkaline urine agent. The pH of urine will increase, making it less acidic. This helps the kidneys to rid themselves of excess uric acid and prevents gout and certain kidney stones.

Uses of Disodium Hydrogen Citrate

Used to reduce the acidity of the urine. Less acidic urine assists the kidneys to remove uric acid, which helps prevent gout and certain kinds of kidney stones (urate). This drug may also prevent and treat certain kidney-related metabolic problems (acidosis). It is a class of medication known as urinary alkalinizers that includes citric acid and citrate salts (which consist of potassium and sodium). As some conditions require your consumption of potassium and sodium, it may depend on the amount of potassium and sodium you can take for your doctor’s choice of the product.

How to Use Disodium Hydrogen Citrate Syrup

Make sure before each dose, shake the container well. Usually, or according to your doctor’s instruction, take this medicine 4 times a day. Take your dose and mix in a full glass of cold water or juices (4-8 ounces or 120-240 milliliters) just before taking your prescribed dose of medicine to help prevent diarrhea and stomach upset, or take the medications you are taking. Slowly drink the whole mix. Ask for additional guidance from your doctor or pharmacist.

The liquid form of this drug must be mixed before taking with a minimum of 4 ounces (120 mg) of water or juice.

Cooling the mixture can improve the taste before drinking. After taking this medication, drink more water or juice, unless your doctor directed it otherwise.

The dose is determined by your medical condition and your treatment response.

As prescribed, take this medicine. Do not increase or take your dose more frequently without the consent of your doctor. Regularly use this medication to make the most of it. Take it every day at the same time to help you remember.

You may have to test your urine pH (acidity) with special paper when you take this medicine. The pH helps to identify the correct dose. For more details, consult your doctor.

Side Effects

Nausea, vomiting, diarrhea, and stomach pain may occur. These side effects can be avoided by mixing the medication with water or juice, taking it after meals, and drinking more fluids. Inform your doctor or right away if any of these side effects persist or become worse.

Remember that your doctor prescribed this medication because he or she believes the benefit to you outweighs the risk of side effects. Many people who take this medication do not experience serious side effects.

Notify your doctor immediately if any of the following unlikely but serious side effects occur: swelling of the hands/ankles/feet, tingling/numbness of the hands/feet, or lack of strength.

If any of the following rare but serious adverse effects occur, contact your doctor immediately: fast/slow/irregular heartbeat, mental/mood changes (e.g., confusion, restlessness), muscle spasms, seizures.

It is uncommon for this drug to cause a severe allergic reaction. But even so, seek immediate medical attention if you notice any of the following symptoms of a severe allergic reaction: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, and difficulty breathing.

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There are some precautions you should consider before taking Disodium Hydrogen Citrate Syrup.

Talk to your doctor if you are hypersensitive to this medication or if you have any some allergies. Inactive ingredients in this drug may cause allergic reactions or other issues. For more information, consult your doctor. 

If you have specified medical conditions, you should not take this medication. Consult your doctor before using this medication if you have severe kidney disease (for instance, if you are unable to produce urine), a sodium-restricted diet, or high sodium levels.

Talk to your doctor about your medical history, particularly if you have: a specific lung condition (pulmonary edema), low calcium levels, high blood pressure, heart problems (e.g., irregular heartbeat, heart failure), kidney disease, or swollen ankles/legs/feet due to water retention (peripheral edema).

This product’s liquid form may taste sweet. If you have diabetes, proceed with caution. Inquire with your doctor or pharmacist about the safe use of this product.

Because this medication consists of sodium (salt), inform your doctor if you are on a salt-restricted diet.

This medication should be used only when clearly necessary during pregnancy. During pregnancy, this medication may worsen high blood pressure (toxemia of pregnancy). Consult your doctor about the risks and benefits.

It is unknown whether this medication passes into breast milk. Before you start breastfeeding, talk to your doctor.



Overdose symptoms could include muscle spasms and seizures.

To track your progress or inspect for side effects, laboratory and/or medical tests (e.g., sodium levels) should indeed be performed on a regular basis. For more information, speak with your doctor.

Alkad - Disodium Hydrogen Citrate Syrup
Alkad – Disodium Hydrogen Citrate Syrup

Missed Dose

If you forget to take a dose, take it as soon as it is possible. If the next dose is approaching, skip the missed dose. Take your upcoming dose at your usual time. To catch up, do not double the dosages.

Storage and Disposal

Store away from light and moisture at room temperature between 68 and 77 degrees Fahrenheit (20 and 25 degrees Celsius). Keep out of the bathroom. Keep all medications out of the reach of children and pets. Do not become paralyzed. Heat should be avoided.

Unless otherwise directed, do not flush medications down the toilet or pour them down the drain. When this product has expired or is no longer needed, properly dispose of it. For more information on how to safely dispose of your product, contact your pharmacist or a local waste disposal company.

Drug Interactions

Your doctor or pharmacist is already aware of potential drug interactions and is keeping an eye out for them. Do not start, stop, or alter the dosage of any medication without first consulting your doctor or pharmacist.

This medication should not be combined with the following medications due to the possibility of serious interactions: aluminum-containing antacids.

Speak to your doctor or pharmacist if you are currently taking any of the medicines listed above before beginning this medication.

Ask your doctor or pharmacist about all prescription and nonprescription/herbal items you use, especially aspirin and other salicylates (e.g., salsalate), lithium, and quinidine.

If your doctor has prescribed low-dose aspirin (81-162 milligrams per day) for heart attack or stroke preventative measures, you should continue taking that unless your doctor instructs you otherwise. For more information, consult your doctor or pharmacist.

This document does not include every possible interaction. As a result, before using this product, inform your doctor or pharmacist of all the products you are currently using. Maintain a list of all your medications and share it with your doctor and pharmacist.

Price of Disodium Hydrogen Citrate Syrup

  • Citralka 100 ml liquid – INR 81.05
  • Citralka 200 ml liquid – INR 107.36
Alkanip - Disodium Hydrogen Citrate Syrup
Alkanip – Disodium Hydrogen Citrate Syrup

Disodium Hydrogen Citrate Summary

To prevent stomach upset, take the medication after meals and with plenty of plain water or juice.

Inform your doctor if you already have severe kidney problems, such as reduced urine output, a sodium-restricted diet, or increased blood sodium levels.

Visit a doctor if you have trouble breathing after taking the medication, or if you have low calcium levels, high blood pressure, heart problems (e.g., irregular heartbeat, heart failure), kidney disease, or swollen ankles/legs/feet due to water retention (peripheral edema).

Inform your doctor if you are pregnant, intend to become pregnant, or are breastfeeding.

Patients who are allergic to disodium hydrogen citrate or any of its ingredients should not be given this medication.

Individuals with a history of high blood potassium levels, congestive heart failure, heart disease, or severe kidney problems, as well as those who are dehydrated, should never be given this medication.

Disodium hydrogen citrate should be avoided by pregnant and breastfeeding women.

Disodium hydrogen citrate should also be avoided by patients suffering from severe bacterial infections.

Frequently Asked Questions(FAQs)

Disodium Hydrogen Citrate is used in what ways?

Disodium Hydrogen Citrate should be taken in the dose and for the duration recommended by your doctor. Shake the bottle thoroughly before each use. As directed by your doctor, mix it in a glass of water or juice. If you have diarrhea, avoid taking Disodium Hydrogen Citrate on an empty stomach. To avoid stomach upset, drink plenty of fluids while taking this medication.

How long would it take to complete the work?

Disodium Hydrogen Citrate takes a few minutes to begin working and has a half-life of four to six hours. To get the most out of it, don’t miss any doses and take it for the full duration recommended by your doctor.

What happens if I overdose?

Taking more Disodium Hydrogen Citrate than your doctor recommends will not help you recover faster. However, it is possible that it will only expose you to increased side effects. As a result, it is recommended that you follow your doctor’s instructions and do not double the dose, even if you forget to take your usual dose.

What exactly does Disodium Hydrogen Citrate do?

Disodium Hydrogen Citrate is a urine alkaliser that reduces uric acid production. As a result, it is beneficial in the treatment and prevention of kidney stones and gout.

Last Updated on February 23, 2022 by Learn From Doctor Team

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